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Section: Science Life |
deutsche Version Print-Version |
Family tree analysis for mammals Gone to the dogs |
In deciding whether humans are more closely related to mice or dogs, ETH researchers went to the dogs. By using as much genetic data and as many different methods as possible, scientists in ETH Zurich Professor Gaston Gonnet’s Computational Biochemistry Research Group concluded that the order of primates is closer to that of carnivores than to that of rodents (1). The corresponding paper was published in the scientific journal PLoS Computational Biology(2). Christoph Meier Relationships between orders of Mammalia are difficult to determine because the respective family trees diverged during a relatively short time at the end of the Cretaceous Period just over 65 million years ago. The consequence of this has been that analyses hitherto have yielded contradictory results: some led to primates being grouped with rodents, as traditional morphological methods have done, while others seemed to show that primates were closer to carnivores. The advantage: data from entire genomes Since the complete genetic data for humans, mice and dogs have become available in the meantime, Gonnet and his colleagues were able to base their analysis on more information than has been available to any previous study. To eliminate possible systematic errors of individual methods, the researchers used more than ten different family tree reconstruction methods. In addition, analyses included genetic data from rats, chimpanzees, macaques and cows. The scientists used a marsupial, the opossum, as an outgroup to “anchor” the mammalian family tree to a root. Although not all the methods used yielded the same relationship distances, the topology of the family tree remained identical. On the scent of the relationship This finding contradicts the theory favoured until now, namely, grouping primates with rodents. According to the ETH scientists, in subsequent analyses there is a need to take yet more genetic data from representatives of the various orders into account in order to obtain additional evidence that primates and carnivores have more recent common ancestors than those they share with rodents. However, if the relationship between primates and carnivores becomes more firmly established, it will also shed new light on the choice of suitable model organisms.
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Finally, the closeness of the relationship between humans and dogs also received support from another scientific discipline not aimed at family tree analysis. Israeli and American researchers discovered that dogs and undergraduates follow odour trails in a similar way (3). When test persons wearing blindfolds and earplugs were asked to follow a chocolate odour trail, they chose a pathway whose shape was similar to that of a dog tracking the scent of a pheasant. |
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